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Prof. Dr. Frank Hahn

Hahn 180x180 Prof. Dr. Frank Hahn
Hahn 180x180

Organische Chemie

Die Arbeitsgruppe Hahn beschäftigt sich mit der Biosynthese und Synthese von Naturstoffen. Wir interessieren uns insbesondere für die an der Biosynthese beteiligten Enzyme, welche wir für eine Verwendung als Biokatalysatoren in der Naturstoffynthese nutzbar machen möchten. 

Hahn 180x180

Organische Chemie

Ausgewählte Publikationen


Sung, Kwang Hoon; Berkhan, Gesche; Hollmann, Tim; Wagner, Lisa Maria Carolin; Blankenfeldt, Wulf; Hahn, Frank
Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain
In: Angewandte Chemie International Edition Bd. 57 (2018) Heft 1. - S. 343-347
doi:10.1002/ange.201707774 ...


Hemmerling, Franziska; Hahn, Frank
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
In: Beilstein Journal of Organic Chemistry Bd. 12 (2016) . - S. 1512-1550
doi:10.3762/bjoc.12.148 ...

Friedrich, Steffen; Hemmerling, Franziska; Lindner, Frederick; Warnke, Anna; Wunderlich, Johannes; Berkhan, Gesche; Hahn, Frank
Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jera ...
In: Molecules Bd. 21 (2016) Heft 11. - S. 1443
doi:10.3390/molecules21111443 ...

Berkhan, Gesche; Merten, Christian; Holec, Claudia; Hahn, Frank
The Interplay between a Multifunctional Dehydratase Domain and a C-Methyltransferase Effects Ol ...
In: Angewandte Chemie International Edition Bd. 55 (2016) Heft 43. - S. 13589-13592
doi:10.1002/anie.201607827 ...


Friedrich, Steffen; Hahn, Frank
Opportunities for enzyme catalysis in natural product chemistry
In: Tetrahedron Bd. 71 (2015) Heft 10. - S. 1473-1508
doi:10.1016/j.tet.2014.12.026 ...


Berkhan, Gesche; Hahn, Frank
A Dehydratase Domain in Ambruticin Biosynthesis Displays Additional Activity as a Pyran-Forming ...
In: Angewandte Chemie International Edition Bd. 53 (2014) Heft 15. - S. 14240-14244
doi:10.1002/anie.201407979 ...

Hemmerling, Franziska; Hahn, Frank
Neue Wege in der Naturstoffforschung: Die erfolgreiche Verbindung von Synthesechemie und Biotec ...
In: GIT-Labor-Fachzeitschrift (2014) Heft 5

Hahn, Frank; Kandziora, Nadine; Friedrich, Steffen; Leadlay, Peter F.
Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis
In: Beilstein Journal of Organic Chemistry Bd. 10 (2014) . - S. 634-640
doi:10.3762/bjoc.10.55 ...

Kandziora, Nadine; Andexer, Jennifer N.; Moss, Steven J.; Wilkinson, Barrie; Leadlay, Peter F.; Hahn, Frank
Uncovering the origin of Z-configured double bonds in polyketides : intermediate E-double bond ...
In: Chemical Science Bd. 5 (2014) Heft 9. - S. 3563-3567
doi:10.1039/C4SC00883A ...


Fürniss, Daniel; Mack, Timo; Hahn, Frank; Vollrath, Sidonie B. L.; Koroniak, Katarzyna; Schepers, Ute; Bräse, Stefan
Peptoids and polyamines going sweet : Modular synthesis of glycosylated peptoids and polyamines ...
In: Beilstein Journal of Organic Chemistry Bd. 9 (2013) . - S. 56-63
doi:10.3762/bjoc.9.7 ...

Kanchanabanca, Chompoonik; Tao, Weixin; Hong, Hui; Liu, Yajing; Hahn, Frank; Samborskyy, Markiyan; Deng, Zixin; Sun, Yuhui; Leadlay, Peter F.
Unusual Acetylation–Elimination in the Formation of Tetronate Antibiotics
In: Angewandte Chemie International Edition Bd. 52 (2013) Heft 22. - S. 5785-5788
doi:10.1002/anie.201301680 ...


Kirschning, Andreas; Hahn, Frank
Merging Chemical Synthesis and Biosynthesis : A New Chapter in the Total Synthesis of Natural P ...
In: Angewandte Chemie International Edition Bd. 51 (2012) Heft 17
doi:10.1002/anie.201107386 ...


Vergnolle, Olivia; Hahn, Frank; Baerga-Ortiz, Abel; Leadlay, Peter F.; Andexer, Jennifer N.
Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase : Impli ...
In: ChemBioChem Bd. 12 (2011) Heft 7. - S. 1011-1014
doi:10.1002/cbic.201100011 ...


Sun, Yuhui; Hahn, Frank; Demydchuk, Yuliya; Chettle, James; Tosin, Manuela; Osada, Hiroyuki; Leadlay, Peter F.
In vitro reconstruction of tetronate RK-682 biosynthesis
In: Nature Chemical Biology Bd. 6 (2010) . - S. 99-101
doi:10.1038/nchembio.285 ...

Schmitz, Katja; Hahn, Frank; Schepers, Ute
Modified GSMP Synthesis Greatly Improves the Disulfide Crosslink of T7 Run-Off siRNAs with Cell ...
In: Synlett Bd. 19 (2010) . - S. 2959-2963
doi:10.1055/s-0030-1259022 ...

Chavarot-Kerlidou, Murielle; Rivard, Michaël; Chamiot, Bénédicte; Hahn, Frank; Rose-Munch, Françoise; Rose, Eric; Py, Sandrine; Herson, Patrick
Synthesis and Structural Characterization of Planar Chiral Cr(CO)3-Complexed Aromatic Nitrones ...
In: European Journal of Organic Chemistry (2010) Heft 5. - S. 944-958
doi:10.1002/ejoc.200900836 ...


Hahn, Frank; Schepers, Ute
Thieme Chemistry Journal Awardees - Where are They Now? : A Convenient Route for Introduction o ...
In: Synlett Bd. 17 (2009) . - S. 2755-2760
doi:10.1055/s-0029-1217987 ...


Hahn, Frank; Schmitz, Katja; Balaban, Theodor S.; Bräse, Stefan
Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Prope ...
In: ChemMedChem Bd. 3 (2008) Heft 8. - S. 1185-1188
doi:10.1002/cmdc.200800013 ...

Hahn, Frank; Müllen, Klaus; Schepers, Ute
2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis
In: Synlett Bd. 18 (2008) . - S. 2785-2790
doi:10.1055/s-0028-1083566 ...

Hahn, Frank; Schepers, Ute
Versatile Procedure for Asymmetric and Orthogonal Protection of Symmetric Polyamines and Its Ad ...
In: Journal of Combinatorial Chemistry Bd. 10 (2008) Heft 2. - S. 267-272
doi:10.1021/cc700119g ...


Hahn, Frank; Schepers, Ute
Solid Phase Chemistry for the Directed Synthesis of Biologically Active Polyamine Analogs, Deri ...
Combinatorial chemistry on solid supports
Berlin : Springer, 2007. - S. 135-208 . - (Topics in Current Chemistry; 278)
https://link.springer.com/content/pdf/10.1007%2F12 ...

Hahn 180x180

Organische Chemie

Prof. Dr. Frank Hahn

Universität Bayreuth
Organische Chemie (Lebensmittelchemie) / NW I
Universitätsstraße 30
95447 Bayreuth

Telefon: +49(0)921-552428
E-Mail: frank.hahn@uni-bayreuth.de
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