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Prof. Dr. Clemens Steegborn

Prof. Dr. Clemens Steegborn

Fakultät für Biologie, Chemie und Geowissenschaften
Lehrstuhl für Biochemie


Job History

02/2010 – presentUniversity of Bayreuth, Dept. Biochemistry, Bayreuth, Germany        
Full Professor (W3) and Chair for Biochemistry
Research topic: Molecular signaling mechanisms in aging and aging-related diseases
03/2005 – 01/2010

Ruhr-University Bochum, Dept. Physiological Chemistry,
Jun.-Professor in Biochemistry
Research topic: Structural and biochemical studies on the regulation of signaling enzymes in aging and disease


Education

12/2001 – 02/2005

Weill Medical College of Cornell University, New York, NY, USA    
Postdoctoral Research Associate in the laboratory of Professor Hao Wu
Research Topic: Structural studies on intracellular signaling systems

10/1997 – 09/2001Max-Planck-Institute of Biochemistry, Martinsried, Germany
Ph.D. in Biochemistry, summa cum laude, March 2001
Thesis Advisor: Professor Robert Huber
Thesis Topic:    Biochemical and X-ray crystallographic studies on transcriptional activator MalT and the pyridoxal-5’-phosphate dependent enzymes cystathionine y-synthase and cystathionine y-lyase
1992 – 1997

University of Bayreuth, Department of Biochemistry, Bayreuth, Germany
Diploma (M.S.) in Biochemistry, passed with distinction, August 1997
Thesis Advisor: Professor Franz-Xaver Schmid
Thesis Topic: Structure of a folding intermediate of ribonuclease T1 studied by NMR spectroscopy


Awards and other responsibilities

2002 – 2005Berger Fellow of the Damon Runyon Cancer Research Foundation
2001Max-Planck postdoctoral fellowship
1998 – 2000“Boehringer Ingelheim Fonds” predoctoral fellowship
1996 – 1997Scholarship of the “Studienstiftung des Deutschen Volkes” foundation
1995European Union TEMPUS scholarship
1991“Fonds der chemischen Industrie” chemistry award
1998“Begabtenfoerderung” (gifted pupils award) by the land Baden-Wuerttemberg
Functions

2010 – presentDeputy Director, Institute for Biomacromolecules (BIOmac), Univ. Bayreuth
06/2012 – 01/2014Speaker, Profile Area “Molecular Biosciences, University of Bayreuth
2012 – presentGerman Society for Biochemistry and Molecular Biology (GBM)

Fakultät für Biologie, Chemie und Geowissenschaften
Lehrstuhl für Biochemie


  • Molecular signalling mechanisms in aging and disease
    - Sirtuin family of deacetylases
    - Cyclic nucleotide signalling
    - Redox enzymes and signalling
  • Protein function and regulation analysis through biochemical studies and x-ray crystallography
  • Structure-assisted drug development

Fakultät für Biologie, Chemie und Geowissenschaften
Lehrstuhl für Biochemie


Ausgewählte Publikationen

2017

Rajabi, Nima; Auth, Marina; Troelsen, Kathrin R.; Pannek, Martin; Bhatt, Dhaval; Fontenas, Martin; Hirshey, Matthew D.; Steegborn, Clemens; Madsen, Andreas S.; Olsen, Christian Adam
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase : Structure-Activity Relationship, ...
In: Angewandte Chemie International Edition (2017)
doi:10.1002/anie.201709050 ...

Li, Jun; Bonkowski, Michael S.; Moniot, Sébastien; Zhang, Dapeng; Hubbard, Basil P.; Ling, Alvin J. Y.; Rajman, Luis A.; Qin, Bo; Lou, Zhenkun; Gorbunova, Vera; Aravind, L.; Steegborn, Clemens; Sinclair, David A.
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
In: Science Bd. 355 (2017) Heft 6331. - S. 1312-1317
doi:10.1126/science.aad8242 ...

Moniot, Sébastien; Forgione, Mariantonietta; Lucidi, Alessia; Hailu, Gebremedhin S.; Nebbioso, Angela; Carafa, Vincenzo; Baratta, Francesca; Altucci, Lucia; Giacché, Nicola; Passeri, Daniela; Pellicciari, Roberto; Mai, Antonello; Steegborn, Clemens; Rotili, Dante
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Si ...
In: Journal of Medicinal Chemistry Bd. 60 (2017) Heft 6. - S. 2344-2360
doi:10.1021/acs.jmedchem.6b01609 ...

Sundriyal, Sandeep; Moniot, Sébastien; Mahmud, Zimam; Yao, Shang; di Fruscia, Paolo; Reynolds, Christopher R.; Dexter, David T.; Sternberg, Michael J. E.; Lam, Eric W.-F.; Steegborn, Clemens; Fuchter, Matthew J.
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Sele ...
In: Journal of Medicinal Chemistry Bd. 60 (2017) Heft 5. - S. 1928-1945
doi:10.1021/acs.jmedchem.6b01690 ...

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; Lázaro, Diana F.; Moniot, Sébastien; Guerreiro, Patrícia; Fonseca, Luis; Marijanovic, Zrinka; Antas, Pedro; Gerhardt, Ellen; Enguita, Francisco Javier; Fauvet, Bruno; Penque, Deborah; Pais, Teresa F.; Tong, Qiang; Becker, Stefan; Kügler, Sebastian; Lashuel, Hilal Ahmed; Steegborn, Clemens; Zweckstetter, Markus; Outeiro, Tiago Fleming
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parki ...
In: PLoS biology Bd. 15 (2017) Heft 3. - S. e2000374
doi:10.1371/journal.pbio.2000374 ...

You, Weijie; Rotili, Dante; Li, Tie-Mei; Kambach, Christian; Meleshin, Marat; Schutkowski, Mike; Chua, Katrin F.; Mai, Antonello; Steegborn, Clemens
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules
In: Angewandte Chemie International Edition Bd. 56 (2017) Heft 4. - S. 1007-1011
doi:10.1002/anie.201610082 ...

Schweizer, Ulrich; Towell, Holly; Vit, Allegra; Rodriguez-Ruiz, Alfonso; Steegborn, Clemens
Structural aspects of thyroid hormone binding to proteins and competitive interactions with nat ...
In: Molecular and Cellular Endocrinology Bd. 458 (2017) . - S. 57-67
doi:10.1016/j.mce.2017.01.026 ...

2016

Ramos-Espiritu, Lavoisier; Kleinbölting, Silke; Navarrete, Felipe A.; Alvau, Antonio; Visconti, Pablo E.; Valsecchi, Federica; Starkov, Anatoly; Manfredi, Giovanni; Buck, Hannes; Adura, Carolina; Zippin, Jonathan H.; van den Heuvel, Joop; Glickman, J. Fraser; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
In: Nature Chemical Biology Bd. 12 (2016) Heft 10. - S. 838-844
doi:10.1038/nchembio.2151 ...

Gertz, Melanie; Steegborn, Clemens
Using mitochondrial sirtuins as drug targets : disease implications and available compounds
In: Cellular and molecular life sciences : CMLS Bd. 73 (2016) Heft 15. - S. 2871-2896
doi:10.1007/s00018-016-2180-7 ...

Quinti, Luisa; Casale, Malcolm; Moniot, Sébastien; Pais, Teresa F.; van Kanegan, Michael J.; Kaltenbach, Linda S.; Pallos, Judit; Lim, Ryan G.; Naidu, Sharadha Dayalan; Runne, Heike; Meisel, Lisa; Rauf, Nazifa Abdul; Leyfer, Dmitriy; Maxwell, Michele M.; Saiah, Eddine; Landers, John E.; Luthi-Carter, Ruth; Abagyan, Ruben; Dinkova-Kostova, Albena T.; Steegborn, Clemens; Marsh, J. Lawrence; Lo, Donald C.; Thompson, Leslie M.; Kazantsev, Aleksey G.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington' ...
In: Cell Chemical Biology Bd. 23 (2016) Heft 7. - S. 849-861
doi:10.1016/j.chembiol.2016.05.015 ...

Kleinbölting, Silke; Ramos-Espiritu, Lavoisier; Buck, Hannes; Colis, Laureen; van den Heuvel, Joop; Glickman, J. Fraser; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric ac ...
In: The Journal of Biological Chemistry Bd. 291 (2016) . - S. 9776-9784
doi:10.1074/jbc.M115.708255 ...

Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial ...
In: Journal of Medicinal Chemistry Bd. 59 (2016) Heft 4. - S. 1471-1491
doi:10.1021/acs.jmedchem.5b01117 ...

Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M; Adams, Peter D; Adeli, Khosrow; Adhihetty, Peter J; Adler, Sharon G; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V; Aguirre-Ghiso, Julio; Airoldi, Edoardo M; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T; Al-Rubeai, Mohamed; Albaiceta, Guillermo M; Albanese, Chris; Albani, Diego; Albert, Matthew L; Aldudo, Jesus; Algül, Hana; Alirezaei, Mehrdad; Alloza, Iraide; Almasan, Alexandru; Almonte-Beceril, Maylin; Alnemri, Emad S; Alonso, Covadonga; Altan-Bonnet, Nihal; Altieri, Dario C; Alvarez, Silvia; Alvarez-Erviti, Lydia; Alves, Sandro; Amadoro, Giuseppina; Amano, Atsuo; Amantini, Consuelo; Ambrosio, Santiago; Amelio, Ivano; Amer, Amal O; Amessou, Mohamed; Amon, Angelika; An, Zhenyi; Anania, Frank A; Andersen, Stig U; Andley, Usha P; Andreadi, Catherine K; Andrieu-Abadie, Nathalie; Anel, Alberto; Ann, David K; Anoopkumar-Dukie, Shailendra; Antonioli, Manuela; Aoki, Hiroshi; Apostolova, Nadezda; Aquila, Saveria; Aquilano, Katia; Araki, Koichi; Arama, Eli; Aranda, Agustin; Araya, Jun; Arcaro, Alexandre; Arias, Esperanza; Arimoto, Hirokazu; Ariosa, Aileen R; Armstrong, Jane L; Arnould, Thierry; Arsov, Ivica; Asanuma, Katsuhiko; Askanas, Valerie; Asselin, Eric; Atarashi, Ryuichiro; Atherton, Sally S; Atkin, Julie D; Attardi, Laura D; Auberger, Patrick; Auburger, Georg; Aurelian, Laure; Autelli, Riccardo; Avagliano, Laura; Avantaggiati, Maria Laura; Avrahami, Limor; Awale, Suresh; Azad, Neelam; Bachetti, Tiziana; Backer, Jonathan M; Bae, Dong-Hun; Bae, Jae-Sung; Bae, Ok-Nam; Bae, Soo Han; Baehrecke, Eric H; Baek, Seung-Hoon; Baghdiguian, Stephen; Bagniewska-Zadworna, Agnieszka; Bai, Hua; Bai, Jie; Bai, Xue-Yuan; Bailly, Yannick; Balaji, Kithiganahalli Narayanaswamy; Balduini, Walter; Ballabio, Andrea; Balzan, Rena; Banerjee, Rajkumar; Bánhegyi, Gábor; Bao, Haijun; Barbeau, Benoit; Barrachina, Maria D; Barreiro, Esther; Bartel, Bonnie; Bartolomé, Alberto; Bassham, Diane C; Bassi, Maria Teresa; Bast, Robert C; Basu, Alakananda; Batista, Maria Teresa; Batoko, Henri; Battino, Maurizio; Bauckman, Kyle; Baumgarner, Bradley L; Bayer, K Ulrich; Beale, Rupert; Beaulieu, Jean-François; Beck, George R; Becker, Christoph; Beckham, J David; Bédard, Pierre-André; Bednarski, Patrick J; Begley, Thomas J; Behl, Christian; Behrends, Christian; Behrens, Georg Mn; Behrns, Kevin E; Bejarano, Eloy; Belaid, Amine; Belleudi, Francesca; Bénard, Giovanni; Berchem, Guy; Bergamaschi, Daniele; Bergami, Matteo; Berkhout, Ben; Berliocchi, Laura; Bernard, Amélie; Bernard, Monique; Bernassola, Francesca; Bertolotti, Anne; Bess, Amanda S; Besteiro, Sébastien; Bettuzzi, Saverio; Bhalla, Savita; Bhattacharyya, Shalmoli; Bhutia, Sujit K; Biagosch, Caroline; Bianchi, Michele Wolfe; Biard-Piechaczyk, Martine; Billes, Viktor; Bincoletto, Claudia; Bingol, Baris; Bird, Sara W; Bitoun, Marc; Bjedov, Ivana; Blackstone, Craig; Blanc, Lionel; Blanco, Guillermo A; Blomhoff, Heidi Kiil; Boada-Romero, Emilio; Böckler, Stefan; Boes, Marianne; Boesze-Battaglia, Kathleen; Boise, Lawrence H; Bolino, Alessandra; Boman, Andrea; Bonaldo, Paolo; Bordi, Matteo; Bosch, Jürgen; Botana, Luis M; Botti, Joelle; Bou, German; Bouché, Marina; Bouchecareilh, Marion; Boucher, Marie-Josée; Boulton, Michael E; Bouret, Sebastien G; Boya, Patricia; Boyer-Guittaut, Michaël; Bozhkov, Peter V; Brady, Nathan; Braga, Vania Mm; Brancolini, Claudio; Braus, Gerhard H.; Bravo-San Pedro, José M; Brennan, Lisa A; Bresnick, Emery H; Brest, Patrick; Bridges, Dave; Bringer, Marie-Agnès; Brini, Marisa; Brito, Glauber C; Brodin, Bertha; Brookes, Paul S; Brown, Eric J; Brown, Karen; Broxmeyer, Hal E; Bruhat, Alain; Brum, Patricia Chakur; Brumell, John H; Brunetti-Pierri, Nicola; Bryson-Richardson, Robert J; Buch, Shilpa; Buchan, Alastair M; Budak, Hikmet; Bulavin, Dmitry V; Bultman, Scott J; Bultynck, Geert; Bumbasirevic, Vladimir; Burelle, Yan; Burke, Robert E; Burmeister, Margit; Bütikofer, Peter; Caberlotto, Laura; Cadwell, Ken; Cahova, Monika; Cai, Dongsheng; Cai, Jingjing; Cai, Qian; Calatayud, Sara; Camougrand, Nadine; Campanella, Michelangelo; Campbell, Grant R; Campbell, Matthew; Campello, Silvia; Candau, Robin; Caniggia, Isabella; Cantoni, Lavinia; Cao, Lizhi; Caplan, Allan B; Caraglia, Michele; Cardinali, Claudio; Cardoso, Sandra Morais; Carew, Jennifer S; Carleton, Laura A; Carlin, Cathleen R; Carloni, Silvia; Carlsson, Sven R; Carmona-Gutierrez, Didac; Carneiro, Leticia Am; Carnevali, Oliana; Carra, Serena; Carrier, Alice; Carroll, Bernadette; Casas, Caty; Casas, Josefina; Cassinelli, Giuliana; Castets, Perrine; Castro-Obregon, Susana; Cavallini, Gabriella; Ceccherini, Isabella; Cecconi, Francesco; Cederbaum, Arthur I; Ceña, Valentín; Cenci, Simone; Cerella, Claudia; Cervia, Davide; Cetrullo, Silvia; Chaachouay, Hassan; Chae, Han-Jung; Chagin, Andrei S; Chai, Chee-Yin; Chakrabarti, Gopal; Chamilos, Georgios; Chan, Edmond Yw; Chan, Matthew Tv; Chandra, Dhyan; Chandra, Pallavi; Chang, Chih-Peng; Chang, Raymond Chuen-Chung; Chang, Ta Yuan; Chatham, John C; Chatterjee, Saurabh; Chauhan, Santosh; Che, Yongsheng; Cheetham, Michael E; Cheluvappa, Rajkumar; Chen, Chun-Jung; Chen, Gang; Chen, Guang-Chao; Chen, Guoqiang; Chen, Hongzhuan; Chen, Jeff W; Chen, Jian-Kang; Chen, Min; Chen, Mingzhou; Chen, Peiwen; Chen, Qi; Chen, Quan; Chen, Shang-Der; Chen, Si; Chen, Steve S-L; Chen, Wei; Chen, Wei-Jung; Chen, Wen Qiang; Chen, Wenli; Chen, Xiangmei; Chen, Yau-Hung; Chen, Ye-Guang; Chen, Yin; Chen, Yingyu; Chen, Yongshun; Chen, Yu-Jen; Chen, Yue-Qin; Chen, Yujie; Chen, Zhen; Chen, Zhong; Cheng, Alan; Cheng, Christopher Hk; Cheng, Hua; Cheong, Heesun; Cherry, Sara; Chesney, Jason; Cheung, Chun Hei Antonio; Chevet, Eric; Chi, Hsiang Cheng; Chi, Sung-Gil; Chiacchiera, Fulvio; Chiang, Hui-Ling; Chiarelli, Roberto; Chiariello, Mario; Chieppa, Marcello; Chin, Lih-Shen; Chiong, Mario; Chiu, Gigi Nc; Cho, Dong-Hyung; Cho, Ssang-Goo; Cho, William C; Cho, Yong-Yeon; Cho, Young-Seok; Choi, Augustine Mk; Choi, Eui-Ju; Choi, Eun-Kyoung; Choi, Jayoung; Choi, Mary E; Choi, Seung-Il; Chou, Tsui-Fen; Chouaib, Salem; Choubey, Divaker; Choubey, Vinay; Chow, Kuan-Chih; Chowdhury, Kamal; Chu, Charleen T; Chuang, Tsung-Hsien; Chun, Taehoon; Chung, Hyewon; Chung, Taijoon; Chung, Yuen-Li; Chwae, Yong-Joon; Cianfanelli, Valentina; Ciarcia, Roberto; Ciechomska, Iwona A; Ciriolo, Maria Rosa; Cirone, Mara; Claerhout, Sofie; Clague, Michael J; Clària, Joan; Clarke, Peter Gh; Clarke, Robert; Clementi, Emilio; Cleyrat, Cédric; Cnop, Miriam; Coccia, Eliana M; Cocco, Tiziana; Codogno, Patrice; Coers, Jörn; Cohen, Ezra Ew; Colecchia, David; Coletto, Luisa; Coll, Núria S; Colucci-Guyon, Emma; Comincini, Sergio; Condello, Maria; Cook, Katherine L; Coombs, Graham H; Cooper, Cynthia D; Cooper, J Mark; Coppens, Isabelle; Corasaniti, Maria Tiziana; Corazzari, Marco; Corbalan, Ramon; Corcelle-Termeau, Elisabeth; Cordero, Mario D; Corral-Ramos, Cristina; Corti, Olga; Cossarizza, Andrea; Costelli, Paola; Costes, Safia; Cotman, Susan L; Coto-Montes, Ana; Cottet, Sandra; Couve, Eduardo; Covey, Lori R; Cowart, L Ashley; Cox, Jeffery S; Coxon, Fraser P; Coyne, Carolyn B; Cragg, Mark S; Craven, Rolf J; Crepaldi, Tiziana; Crespo, Jose L; Criollo, Alfredo; Crippa, Valeria; Cruz, Maria Teresa; Cuervo, Ana Maria; Cuezva, Jose M; Cui, Taixing; Cutillas, Pedro R; Czaja, Mark J; Czyzyk-Krzeska, Maria F; Dagda, Ruben K; Dahmen, Uta; Dai, Chunsun; Dai, Wenjie; Dai, Yun; Dalby, Kevin N; Dalla Valle, Luisa; Dalmasso, Guillaume; D'Amelio, Marcello; Damme, Markus; Darfeuille-Michaud, Arlette; Dargemont, Catherine; Darley-Usmar, Victor M; Dasarathy, Srinivasan; Dasgupta, Biplab; Dash, Srikanta; Dass, Crispin R; Davey, Hazel Marie; Davids, Lester M; Dávila, David; Davis, Roger J; Dawson, Ted M; Dawson, Valina L; Daza, Paula; de Belleroche, Jackie; de Figueiredo, Paul; de Figueiredo, Regina Celia Bressan Queiroz; de la Fuente, José; De Martino, Luisa; De Matteis, Antonella; De Meyer, Guido Ry; De Milito, Angelo; De Santi, Mauro; de Souza, Wanderley; De Tata, Vincenzo; De Zio, Daniela; Debnath, Jayanta; Dechant, Reinhard; Decuypere, Jean-Paul; Deegan, Shane; Dehay, Benjamin; Del Bello, Barbara; Del Re, Dominic P; Delage-Mourroux, Régis; Delbridge, Lea Md; Deldicque, Louise; Delorme-Axford, Elizabeth; Deng, Yizhen; Dengjel, Joern; Denizot, Melanie; Dent, Paul; Der, Channing J; Deretic, Vojo; Derrien, Benoît; Deutsch, Eric; Devarenne, Timothy P; Devenish, Rodney J; Di Bartolomeo, Sabrina; Di Daniele, Nicola; Di Domenico, Fabio; Di Nardo, Alessia; Di Paola, Simone; Di Pietro, Antonio; Di Renzo, Livia; DiAntonio, Aaron; Díaz-Araya, Guillermo; Díaz-Laviada, Ines; Diaz-Meco, Maria T; Diaz-Nido, Javier; Dickey, Chad A; Dickson, Robert C; Diederich, Marc; Digard, Paul; Dikic, Ivan; Dinesh-Kumar, Savithrama P; Ding, Chan; Ding, Wen-Xing; Ding, Zufeng; Dini, Luciana; Distler, Jörg Hw; Diwan, Abhinav; Djavaheri-Mergny, Mojgan; Dmytruk, Kostyantyn; Dobson, Renwick Cj; Doetsch, Volker; Dokladny, Karol; Dokudovskaya, Svetlana; Donadelli, Massimo; Dong, X Charlie; Dong, Xiaonan; Dong, Zheng; Donohue, Terrence M; Doran, Kelly S; D'Orazi, Gabriella; Dorn, Gerald W; Dosenko, Victor; Dridi, Sami; Drucker, Liat; Du, Jie; Du, Li-Lin; Du, Lihuan; du Toit, André; Dua, Priyamvada; Duan, Lei; Duann, Pu; Dubey, Vikash Kumar; Duchen, Michael R; Duchosal, Michel A; Duez, Helene; Dugail, Isabelle; Dumit, Verónica I; Duncan, Mara C; Dunlop, Elaine A; Dunn, William A; Dupont, Nicolas; Dupuis, Luc; Durán, Raúl V; Durcan, Thomas M; Duvezin-Caubet, Stéphane; Duvvuri, Umamaheswar; Eapen, Vinay; Ebrahimi-Fakhari, Darius; Echard, Arnaud; Eckhart, Leopold; Edelstein, Charles L; Edinger, Aimee L; Eichinger, Ludwig; Eisenberg, Tobias; Eisenberg-Lerner, Avital; Eissa, N Tony; El-Deiry, Wafik S; El-Khoury, Victoria; Elazar, Zvulun; Eldar-Finkelman, Hagit; Elliott, Chris Jh; Emanuele, Enzo; Emmenegger, Urban; Engedal, Nikolai; Engelbrecht, Anna-Mart; Engelender, Simone; Enserink, Jorrit M; Erdmann, Ralf; Erenpreisa, Jekaterina; Eri, Rajaraman; Eriksen, Jason L; Erman, Andreja; Escalante, Ricardo; Eskelinen, Eeva-Liisa; Espert, Lucile; Esteban-Martínez, Lorena; Evans, Thomas J; Fabri, Mario; Fabrias, Gemma; Fabrizi, Cinzia; Facchiano, Antonio; Færgeman, Nils J; Faggioni, Alberto; Fairlie, W Douglas; Fan, Chunhai; Fan, Daping; Fan, Jie; Fang, Shengyun; Fanto, Manolis; Fanzani, Alessandro; Farkas, Thomas; Faure, Mathias; Favier, Francois B; Fearnhead, Howard; Federici, Massimo; Fei, Erkang; Felizardo, Tania C; Feng, Hua; Feng, Yibin; Feng, Yuchen; Ferguson, Thomas A; Fernández, Álvaro F; Fernandez-Barrena, Maite G; Fernandez-Checa, Jose C; Fernández-López, Arsenio; Fernandez-Zapico, Martin E; Feron, Olivier; Ferraro, Elisabetta; Ferreira-Halder, Carmen Veríssima; Fesus, Laszlo; Feuer, Ralph; Fiesel, Fabienne C; Filippi-Chiela, Eduardo C; Filomeni, Giuseppe; Fimia, Gian Maria; Fingert, John H; Finkbeiner, Steven; Finkel, Toren; Fiorito, Filomena; Fisher, Paul B; Flajolet, Marc; Flamigni, Flavio; Florey, Oliver; Florio, Salvatore; Floto, R Andres; Folini, Marco; Follo, Carlo; Fon, Edward A; Fornai, Francesco; Fortunato, Franco; Fraldi, Alessandro; Franco, Rodrigo; Francois, Arnaud; François, Aurélie; Frankel, Lisa B; Fraser, Iain Dc; Frey, Norbert; Freyssenet, Damien G; Frezza, Christian; Friedman, Scott L; Frigo, Daniel E; Fu, Dongxu; Fuentes, José M; Fueyo, Juan; Fujitani, Yoshio; Fujiwara, Yuuki; Fujiya, Mikihiro; Fukuda, Mitsunori; Fulda, Simone; Fusco, Carmela; Gabryel, Bozena; Gaestel, Matthias; Gailly, Philippe; Gajewska, Malgorzata; Galadari, Sehamuddin; Galili, Gad; Galindo, Inmaculada; Galindo, Maria F; Galliciotti, Giovanna; Galluzzi, Lorenzo; Galluzzi, Luca; Galy, Vincent; Gammoh, Noor; Gandy, Sam; Ganesan, Anand K; Ganesan, Swamynathan; Ganley, Ian G; Gannagé, Monique; Gao, Fen-Biao; Gao, Feng; Gao, Jian-Xin; García Nannig, Lorena; García Véscovi, Eleonora; Garcia-Macía, Marina; Garcia-Ruiz, Carmen; Garg, Abhishek D; Garg, Pramod Kumar; Gargini, Ricardo; Gassen, Nils Christian; Gatica, Damián; Gatti, Evelina; Gavard, Julie; Gavathiotis, Evripidis; Ge, Liang; Ge, Pengfei; Ge, Shengfang; Gean, Po-Wu; Gelmetti, Vania; Genazzani, Armando A; Geng, Jiefei; Genschik, Pascal; Gerner, Lisa; Gestwicki, Jason E; Gewirtz, David A; Ghavami, Saeid; Ghigo, Eric; Ghosh, Debabrata; Giammarioli, Anna Maria; Giampieri, Francesca; Giampietri, Claudia; Giatromanolaki, Alexandra; Gibbings, Derrick J; Gibellini, Lara; Gibson, Spencer B; Ginet, Vanessa; Giordano, Antonio; Giorgini, Flaviano; Giovannetti, Elisa; Girardin, Stephen E; Gispert, Suzana; Giuliano, Sandy; Gladson, Candece L; Glavic, Alvaro; Gleave, Martin; Godefroy, Nelly; Gogal, Robert M; Gokulan, Kuppan; Goldman, Gustavo H; Goletti, Delia; Goligorsky, Michael S; Gomes, Aldrin V; Gomes, Ligia C; Gomez, Hernando; Gomez-Manzano, Candelaria; Gómez-Sánchez, Rubén; Gonçalves, Dawit Ap; Goncu, Ebru; Gong, Qingqiu; Gongora, Céline; Gonzalez, Carlos B; Gonzalez-Alegre, Pedro; Gonzalez-Cabo, Pilar; González-Polo, Rosa Ana; Goping, Ing Swie; Gorbea, Carlos; Gorbunov, Nikolai V; Goring, Daphne R; Gorman, Adrienne M; Gorski, Sharon M; Goruppi, Sandro; Goto-Yamada, Shino; Gotor, Cecilia; Gottlieb, Roberta A; Gozes, Illana; Gozuacik, Devrim; Graba, Yacine; Graef, Martin; Granato, Giovanna E; Grant, Gary Dean; Grant, Steven; Gravina, Giovanni Luca; Green, Douglas R; Greenhough, Alexander; Greenwood, Michael T; Grimaldi, Benedetto; Gros, Frédéric; Grose, Charles; Groulx, Jean-Francois; Gruber, Florian; Grumati, Paolo; Grune, Tilman; Guan, Jun-Lin; Guan, Kun-Liang; Guerra, Barbara; Guillen, Carlos; Gulshan, Kailash; Gunst, Jan; Guo, Chuanyong; Guo, Lei; Guo, Ming; Guo, Wenjie; Guo, Xu-Guang; Gust, Andrea A; Gustafsson, Åsa B; Gutierrez, Elaine; Gutierrez, Maximiliano G; Gwak, Ho-Shin; Haas, Albert; Haber, James E; Hadano, Shinji; Hagedorn, Monica; Hahn, David R; Halayko, Andrew J; Hamacher-Brady, Anne; Hamada, Kozo; Hamai, Ahmed; Hamann, Andrea; Hamasaki, Maho; Hamer, Isabelle; Hamid, Qutayba; Hammond, Ester M; Han, Feng; Han, Weidong; Handa, James T; Hanover, John A; Hansen, Malene; Harada, Masaru; Harhaji-Trajkovic, Ljubica; Harper, J Wade; Harrath, Abdel Halim; Harris, Adrian L; Harris, James; Hasler, Udo; Hasselblatt, Peter; Hasui, Kazuhisa; Hawley, Robert G; Hawley, Teresa S; He, Congcong; He, Cynthia Y; He, Fengtian; He, Gu; He, Rong-Rong; He, Xian-Hui; He, You-Wen; He, Yu-Ying; Heath, Joan K; Hébert, Marie-Josée; Heinzen, Robert A; Helgason, Gudmundur Vignir; Hensel, Michael; Henske, Elizabeth P; Her, Chengtao; Herman, Paul K; Hernández, Agustín; Hernandez, Carlos; Hernández-Tiedra, Sonia; Hetz, Claudio; Hiesinger, P Robin; Higaki, Katsumi; Hilfiker, Sabine; Hill, Bradford G; Hill, Joseph A; Hill, William D; Hino, Keisuke; Hofius, Daniel; Hofman, Paul; Höglinger, Günter U; Höhfeld, Jörg; Holz, Marina K; Hong, Yonggeun; Hood, David A; Hoozemans, Jeroen Jm; Hoppe, Thorsten; Hsu, Chin; Hsu, Chin-Yuan; Hsu, Li-Chung; Hu, Dong; Hu, Guochang; Hu, Hong-Ming; Hu, Hongbo; Hu, Ming Chang; Hu, Yu-Chen; Hu, Zhuo-Wei; Hua, Fang; Hua, Ya; Huang, Canhua; Huang, Huey-Lan; Huang, Kuo-How; Huang, Kuo-Yang; Huang, Shile; Huang, Shiqian; Huang, Wei-Pang; Huang, Yi-Ran; Huang, Yong; Huang, Yunfei; Huber, Tobias B; Huebbe, Patricia; Huh, Won-Ki; Hulmi, Juha J; Hur, Gang Min; Hurley, James H; Husak, Zvenyslava; Hussain, Sabah Na; Hussain, Salik; Hwang, Jung Jin; Hwang, Seungmin; Hwang, Thomas Is; Ichihara, Atsuhiro; Imai, Yuzuru; Imbriano, Carol; Inomata, Megumi; Into, Takeshi; Iovane, Valentina; Iovanna, Juan L; Iozzo, Renato V; Ip, Nancy Y; Irazoqui, Javier E; Iribarren, Pablo; Isaka, Yoshitaka; Isakovic, Aleksandra J; Ischiropoulos, Harry; Isenberg, Jeffrey S; Ishaq, Mohammad; Ishida, Hiroyuki; Ishii, Isao; Ishmael, Jane E; Isidoro, Ciro; Isobe, Ken-Ichi; Isono, Erika; Issazadeh-Navikas, Shohreh; Itahana, Koji; Itakura, Eisuke; Ivanov, Andrei I; Iyer, Anand Krishnan V; Izquierdo, José M; Izumi, Yotaro; Izzo, Valentina; Jäättelä, Marja; Jaber, Nadia; Jackson, Daniel John; Jackson, William T; Jacob, Tony George; Jacques, Thomas S; Jagannath, Chinnaswamy; Jain, Ashish; Jana, Nihar Ranjan; Jang, Byoung Kuk; Jani, Alkesh; Janji, Bassam; Jannig, Paulo Roberto; Jansson, Patric J; Jean, Steve; Jendrach, Marina; Jeon, Ju-Hong; Jessen, Niels; Jeung, Eui-Bae; Jia, Kailiang; Jia, Lijun; Jiang, Hong; Jiang, Hongchi; Jiang, Liwen; Jiang, Teng; Jiang, Xiaoyan; Jiang, Xuejun; Jiang, Xuejun; Jiang, Ying; Jiang, Yongjun; Jiménez, Alberto; Jin, Cheng; Jin, Hongchuan; Jin, Lei; Jin, Meiyan; Jin, Shengkan; Jinwal, Umesh Kumar; Jo, Eun-Kyeong; Johansen, Terje; Johnson, Daniel E; Johnson, Gail Vw; Johnson, James D; Jonasch, Eric; Jones, Chris; Joosten, Leo Ab; Jordan, Joaquin; Joseph, Anna-Maria; Joseph, Bertrand; Joubert, Annie M; Ju, Dianwen; Ju, Jingfang; Juan, Hsueh-Fen; Juenemann, Katrin; Juhász, Gábor; Jung, Hye Seung; Jung, Jae U; Jung, Yong-Keun; Jungbluth, Heinz; Justice, Matthew J; Jutten, Barry; Kaakoush, Nadeem O; Kaarniranta, Kai; Kaasik, Allen; Kabuta, Tomohiro; Kaeffer, Bertrand; Kågedal, Katarina; Kahana, Alon; Kajimura, Shingo; Kakhlon, Or; Kalia, Manjula; Kalvakolanu, Dhan V; Kamada, Yoshiaki; Kambas, Konstantinos; Kaminskyy, Vitaliy O; Kampinga, Harm H; Kandouz, Mustapha; Kang, Chanhee; Kang, Rui; Kang, Tae-Cheon; Kanki, Tomotake; Kanneganti, Thirumala-Devi; Kanno, Haruo; Kanthasamy, Anumantha G; Kantorow, Marc; Kaparakis-Liaskos, Maria; Kapuy, Orsolya; Karantza, Vassiliki; Karim, Md Razaul; Karmakar, Parimal; Kaser, Arthur; Kaushik, Susmita; Kawula, Thomas; Kaynar, A Murat; Ke, Po-Yuan; Ke, Zun-Ji; Kehrl, John H; Keller, Kate E; Kemper, Jongsook Kim; Kenworthy, Anne K; Kepp, Oliver; Kern, Andreas; Kesari, Santosh; Kessel, David; Ketteler, Robin; Kettelhut, Isis do Carmo; Khambu, Bilon; Khan, Muzamil Majid; Khandelwal, Vinoth Km; Khare, Sangeeta; Kiang, Juliann G; Kiger, Amy A; Kihara, Akio; Kim, Arianna L; Kim, Cheol Hyeon; Kim, Deok Ryong; Kim, Do-Hyung; Kim, Eung Kweon; Kim, Hye Young; Kim, Hyung-Ryong; Kim, Jae-Sung; Kim, Jeong Hun; Kim, Jin Cheon; Kim, Jin Hyoung; Kim, Kwang Woon; Kim, Michael D; Kim, Moon-Moo; Kim, Peter K; Kim, Seong Who; Kim, Soo-Youl; Kim, Yong-Sun; Kim, Yonghyun; Kimchi, Adi; Kimmelman, Alec C; Kimura, Tomonori; King, Jason S; Kirkegaard, Karla; Kirkin, Vladimir; Kirshenbaum, Lorrie A; Kishi, Shuji; Kitajima, Yasuo; Kitamoto, Katsuhiko; Kitaoka, Yasushi; Kitazato, Kaio; Kley, Rudolf A; Klimecki, Walter T; Klinkenberg, Michael; Klucken, Jochen; Knævelsrud, Helene; Knecht, Erwin; Knuppertz, Laura; Ko, Jiunn-Liang; Kobayashi, Satoru; Koch, Jan C; Koechlin-Ramonatxo, Christelle; Koenig, Ulrich; Koh, Young Ho; Köhler, Katja; Kohlwein, Sepp D; Koike, Masato; Komatsu, Masaaki; Kominami, Eiki; Kong, Dexin; Kong, Hee Jeong; Konstantakou, Eumorphia G; Kopp, Benjamin T; Korcsmaros, Tamas; Korhonen, Laura; Korolchuk, Viktor I; Koshkina, Nadya V; Kou, Yanjun; Koukourakis, Michael I; Koumenis, Constantinos; Kovács, Attila L; Kovács, Tibor; Kovacs, Werner J; Koya, Daisuke; Kraft, Claudine; Krainc, Dimitri; Kramer, Helmut; Kravic-Stevovic, Tamara; Krek, Wilhelm; Kretz-Remy, Carole; Krick, Roswitha; Krishnamurthy, Malathi; Kriston-Vizi, Janos; Kroemer, Guido; Kruer, Michael C; Kruger, Rejko; Ktistakis, Nicholas T; Kuchitsu, Kazuyuki; Kuhn, Christian; Kumar, Addanki Pratap; Kumar, Anuj; Kumar, Ashok; Kumar, Deepak; Kumar, Dhiraj; Kumar, Rakesh; Kumar, Sharad; Kundu, Mondira; Kung, Hsing-Jien; Kuno, Atsushi; Kuo, Sheng-Han; Kuret, Jeff; Kurz, Tino; Kwok, Terry; Kwon, Taeg Kyu; Kwon, Yong Tae; Kyrmizi, Irene; La Spada, Albert R; Lafont, Frank; Lahm, Tim; Lakkaraju, Aparna; Lam, Truong; Lamark, Trond; Lancel, Steve; Landowski, Terry H; Lane, Darius Jr; Lane, Jon D; Lanzi, Cinzia; Lapaquette, Pierre; Lapierre, Louis R; Laporte, Jocelyn; Laukkarinen, Johanna; Laurie, Gordon W; Lavandero, Sergio; Lavie, Lena; LaVoie, Matthew J; Law, Betty Yuen Kwan; Law, Helen Ka-Wai; Law, Kelsey B; Layfield, Robert; Lazo, Pedro A; Le Cam, Laurent; Le Roch, Karine G; Le Stunff, Hervé; Leardkamolkarn, Vijittra; Lecuit, Marc; Lee, Byung-Hoon; Lee, Che-Hsin; Lee, Erinna F; Lee, Gyun Min; Lee, He-Jin; Lee, Hsinyu; Lee, Jae Keun; Lee, Jongdae; Lee, Ju-Hyun; Lee, Jun Hee; Lee, Michael; Lee, Myung-Shik; Lee, Patty J; Lee, Sam W; Lee, Seung-Jae; Lee, Shiow-Ju; Lee, Stella Y; Lee, Sug Hyung; Lee, Sung Sik; Lee, Sung-Joon; Lee, Sunhee; Lee, Ying-Ray; Lee, Yong J; Lee, Young H; Leeuwenburgh, Christiaan; Lefort, Sylvain; Legouis, Renaud; Lei, Jinzhi; Lei, Qun-Ying; Leib, David A; Leibowitz, Gil; Lekli, Istvan; Lemaire, Stéphane D; Lemasters, John J; Lemberg, Marius K; Lemoine, Antoinette; Leng, Shuilong; Lenz, Guido; Lenzi, Paola; Lerman, Lilach O; Lettieri Barbato, Daniele; Leu, Julia I-Ju; Leung, Hing Y; Levine, Beth; Lewis, Patrick A; Lezoualc'h, Frank; Li, Chi; Li, Faqiang; Li, Feng-Jun; Li, Jun; Li, Ke; Li, Lian; Li, Min; Li, Min; Li, Qiang; Li, Rui; Li, Sheng; Li, Wei; Li, Wei; Li, Xiaotao; Li, Yumin; Lian, Jiqin; Liang, Chengyu; Liang, Qiangrong; Liao, Yulin; Liberal, Joana; Liberski, Pawel P; Lie, Pearl; Lieberman, Andrew P; Lim, Hyunjung Jade; Lim, Kah-Leong; Lim, Kyu; Lima, Raquel T; Lin, Chang-Shen; Lin, Chiou-Feng; Lin, Fang; Lin, Fangming; Lin, Fu-Cheng; Lin, Kui; Lin, Kwang-Huei; Lin, Pei-Hui; Lin, Tianwei; Lin, Wan-Wan; Lin, Yee-Shin; Lin, Yong; Linden, Rafael; Lindholm, Dan; Lindqvist, Lisa M; Lingor, Paul; Linkermann, Andreas; Liotta, Lance A; Lipinski, Marta M; Lira, Vitor A; Lisanti, Michael P; Liton, Paloma B; Liu, Bo; Liu, Chong; Liu, Chun-Feng; Liu, Fei; Liu, Hung-Jen; Liu, Jianxun; Liu, Jing-Jing; Liu, Jing-Lan; Liu, Ke; Liu, Leyuan; Liu, Liang; Liu, Quentin; Liu, Rong-Yu; Liu, Shiming; Liu, Shuwen; Liu, Wei; Liu, Xian-De; Liu, Xiangguo; Liu, Xiao-Hong; Liu, Xinfeng; Liu, Xu; Liu, Xueqin; Liu, Yang; Liu, Yule; Liu, Zexian; Liu, Zhe; Liuzzi, Juan P; Lizard, Gérard; Ljujic, Mila; Lodhi, Irfan J; Logue, Susan E; Lokeshwar, Bal L; Long, Yun Chau; Lonial, Sagar; Loos, Benjamin; López-Otín, Carlos; López-Vicario, Cristina; Lorente, Mar; Lorenzi, Philip L; Lõrincz, Péter; Los, Marek; Lotze, Michael T; Lovat, Penny E; Lu, Binfeng; Lu, Bo; Lu, Jiahong; Lu, Qing; Lu, She-Min; Lu, Shuyan; Lu, Yingying; Luciano, Frédéric; Luckhart, Shirley; Lucocq, John Milton; Ludovico, Paula; Lugea, Aurelia; Lukacs, Nicholas W; Lum, Julian J; Lund, Anders H; Luo, Honglin; Luo, Jia; Luo, Shouqing; Luparello, Claudio; Lyons, Timothy; Ma, Jianjie; Ma, Yi; Ma, Yong; Ma, Zhenyi; Machado, Juliano; Machado-Santelli, Glaucia M; Macian, Fernando; MacIntosh, Gustavo C; MacKeigan, Jeffrey P; Macleod, Kay F; MacMicking, John D; MacMillan-Crow, Lee Ann; Madeo, Frank; Madesh, Muniswamy; Madrigal-Matute, Julio; Maeda, Akiko; Maeda, Tatsuya; Maegawa, Gustavo; Maellaro, Emilia; Maes, Hannelore; Magariños, Marta; Maiese, Kenneth; Maiti, Tapas K; Maiuri, Luigi; Maiuri, Maria Chiara; Maki, Carl G; Malli, Roland; Malorni, Walter; Maloyan, Alina; Mami-Chouaib, Fathia; Man, Na; Mancias, Joseph D; Mandelkow, Eva-Maria; Mandell, Michael A; Manfredi, Angelo A; Manié, Serge N; Manzoni, Claudia; Mao, Kai; Mao, Zixu; Mao, Zong-Wan; 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Pinti, Marcello; Pinton, Paolo; Piperdi, Bilal; Piret, James M; Platanias, Leonidas C; Platta, Harald W; Plowey, Edward D; Pöggeler, Stefanie; Poirot, Marc; Polčic, Peter; Poletti, Angelo; Poon, Audrey H; Popelka, Hana; Popova, Blagovesta; Poprawa, Izabela; Poulose, Shibu M; Poulton, Joanna; Powers, Scott K; Powers, Ted; Pozuelo-Rubio, Mercedes; Prak, Krisna; Prange, Reinhild; Prescott, Mark; Priault, Muriel; Prince, Sharon; Proia, Richard L; Proikas-Cezanne, Tassula; Prokisch, Holger; Promponas, Vasilis J; Przyklenk, Karin; Puertollano, Rosa; Pugazhenthi, Subbiah; Puglielli, Luigi; Pujol, Aurora; Puyal, Julien; Pyeon, Dohun; Qi, Xin; Qian, Wen-Bin; Qin, Zheng-Hong; Qiu, Yu; Qu, Ziwei; Quadrilatero, Joe; Quinn, Frederick; Raben, Nina; Rabinowich, Hannah; Radogna, Flavia; Ragusa, Michael J; Rahmani, Mohamed; Raina, Komal; Ramanadham, Sasanka; Ramesh, Rajagopal; Rami, Abdelhaq; Randall-Demllo, Sarron; Randow, Felix; Rao, Hai; Rao, V Ashutosh; Rasmussen, Blake B; Rasse, Tobias M; Ratovitski, Edward A; Rautou, Pierre-Emmanuel; Ray, Swapan K; Razani, Babak; Reed, Bruce H; Reggiori, Fulvio; Rehm, Markus; Reichert, Andreas S; Rein, Theo; Reiner, David J; Reits, Eric; Ren, Jun; Ren, Xingcong; Renna, Maurizio; Reusch, Jane Eb; Revuelta, Jose L; Reyes, Leticia; Rezaie, Alireza R; Richards, Robert I; Richardson, Des R; Richetta, Clémence; Riehle, Michael A; Rihn, Bertrand H; Rikihisa, Yasuko; Riley, Brigit E; Rimbach, Gerald; Rippo, Maria Rita; Ritis, Konstantinos; Rizzi, Federica; Rizzo, Elizete; Roach, Peter J; Robbins, Jeffrey; Roberge, Michel; Roca, Gabriela; Roccheri, Maria Carmela; Rocha, Sonia; Rodrigues, Cecilia Mp; Rodríguez, Clara I; de Cordoba, Santiago Rodriguez; Rodriguez-Muela, Natalia; Roelofs, Jeroen; Rogov, Vladimir V; Rohn, Troy T; Rohrer, Bärbel; Romanelli, Davide; Romani, Luigina; Romano, Patricia Silvia; Roncero, M Isabel G; Rosa, Jose Luis; Rosello, Alicia; Rosen, Kirill V; Rosenstiel, Philip; Rost-Roszkowska, Magdalena; Roth, Kevin A; Roué, Gael; Rouis, Mustapha; Rouschop, Kasper M; 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Shapiro, Irving M; Sharma, Shweta; She, Hua; Shen, C-K James; Shen, Chiung-Chyi; Shen, Han-Ming; Shen, Sanbing; Shen, Weili; Sheng, Rui; Sheng, Xianyong; Sheng, Zu-Hang; Shepherd, Trevor G; Shi, Junyan; Shi, Qiang; Shi, Qinghua; Shi, Yuguang; Shibutani, Shusaku; Shibuya, Kenichi; Shidoji, Yoshihiro; Shieh, Jeng-Jer; Shih, Chwen-Ming; Shimada, Yohta; Shimizu, Shigeomi; Shin, Dong Wook; Shinohara, Mari L; Shintani, Michiko; Shintani, Takahiro; Shioi, Tetsuo; Shirabe, Ken; Shiri-Sverdlov, Ronit; Shirihai, Orian; Shore, Gordon C; Shu, Chih-Wen; Shukla, Deepak; Sibirny, Andriy A; Sica, Valentina; Sigurdson, Christina J; Sigurdsson, Einar M; Sijwali, Puran Singh; Sikorska, Beata; Silveira, Wilian A; Silvente-Poirot, Sandrine; Silverman, Gary A; Simak, Jan; Simmet, Thomas; Simon, Anna Katharina; Simon, Hans-Uwe; Simone, Cristiano; Simons, Matias; Simonsen, Anne; Singh, Rajat; Singh, Shivendra V; Singh, Shrawan K; Sinha, Debasish; Sinha, Sangita; Sinicrope, Frank A; Sirko, Agnieszka; Sirohi, Kapil; 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Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd edition)
In: Autophagy Bd. 12 (2016) Heft 1. - S. 1-222
doi:10.1080/15548627.2015.1100356 ...

Schuster, Sabine; Roessler, Claudia; Meleshin, Marat; Zimmermann, Philipp; Simic, Zeljko; Kambach, Christian; Schiene-Fischer, Cordelia; Steegborn, Clemens; Hottiger, Michael O.; Schutkowski, Mike
A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
In: Scientific Reports Bd. 6 (2016) . - S. 22643
doi:10.1038/srep22643 ...

Suenkel, Benjamin; Steegborn, Clemens
Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Hi ...
In: Methods in Enzymology Bd. 573 (2016) . - S. 183-208
doi:10.1016/bs.mie.2015.12.004 ...

2015

Simic, Zeljko; Weiwad, Matthias; Schierhorn, Angelika; Steegborn, Clemens; Schutkowski, Mike
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by ...
In: ChemBioChem Bd. 16 (2015) Heft 16. - S. 2337-2347
doi:10.1002/cbic.201500364 ...

Schweizer, Ulrich; Steegborn, Clemens
New insights into the structure and mechanism of iodothyronine deiodinases
In: Journal of Molecular Endocrinology Bd. 56 (2015) Heft 2. - S. R37-R52
doi:10.1530/JME-15-0156 ...

Schweizer, Ulrich; Steegborn, Clemens
Thyroid hormones - From Crystal Packing to Activity to Reactivity
In: Angewandte Chemie International Edition (2015)
doi:10.1002/anie.201506919 ...

Roessler, Claudia; Tüting, Christian; Meleshin, Marat; Steegborn, Clemens; Schutkowski, Mike
A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases
In: Journal of Medicinal Chemistry (2015)
doi:10.1021/acs.jmedchem.5b00293 ...

Banerjee, Arka; Adolph, Ramona S.; Gopalakrishnapai, Jayashree; Kleinbölting, Silke; Emmerich, Christiane; Steegborn, Clemens; Visweswariah, Sandhya S.
A Universal Stress Protein (USP) in Mycobacteria binds cAMP.
In: The Journal of Biological Chemistry (2015)
doi:10.1074/jbc.M115.644856 ...

Polletta, Lucia; Vernucci, Enza; Carnevale, Ilaria; Arcangeli, Tania; Rotili, Dante; Palmerio, Silvia; Steegborn, Clemens; Nowak, Theresa; Schutkowski, Mike; Pellegrini, Laura; Sansone, Luigi; Villanova, Lidia; Runci, Alessandra; Pucci, Bruna; Morgante, Emanuela; Fini, Massimo; Mai, Antonello; Russo, Matteo A.; Tafani, Marco
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
In: Autophagy Bd. 11 (2015) Heft 2. - S. 253-270
doi:10.1080/15548627.2015.1009778 ...

di Fruscia, Paolo; Zacharioudakis, Emmanouil; Liu, Chang; Moniot, Sébastien; Laohasinnarong, Sasiwan; Khongkow, Mattaka; Harrison, Ian F.; Koltsida, Konstantina; Reynolds, Christopher R.; Schmidtkunz, Karin; Jung, Manfred; Chapman, Kathryn L.; Steegborn, Clemens; Dexter, David T.; Sternberg, Michael J. E.; Lam, Eric W.-F.; Fuchter, Matthew J.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-on ...
In: ChemMedChem Bd. 10 (2015) Heft 1. - S. 69-82
doi:10.1002/cmdc.201402431 ...

Fränzel, Benjamin; Fischer, Frank; Steegborn, Clemens; Wolters, Dirk
Proteinase K improves quantitative acylation studies
In: Proteomics Bd. 15 (2015) Heft 1. - S. 44-47
doi:10.1002/pmic.201400015 ...

Rumpf, Tobias; Schiedel, Matthias; Karaman, Berin; Roessler, Claudia; North, Brian J.; Lehotzky, Attila; Oláh, Judit; Ladwein, Kathrin I.; Schmidtkunz, Karin; Gajer, Markus; Pannek, Martin; Steegborn, Clemens; Sinclair, David A.; Gerhardt, Stefan; Ovádi, Judit; Schutkowski, Mike; Sippl, Wolfgang; Einsle, Oliver; Jung, Manfred
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
In: Nature Communications Bd. 6 (2015) . - S. 6263
doi:10.1038/ncomms7263 ...

Chen, Xiqun; Wales, Pauline; Quinti, Luisa; Zuo, Fuxing; Moniot, Sébastien; Herisson, Fanny; Rauf, Nazifa Abdul; Wang, Hua; Silverman, Richard B.; Ayata, Cenk; Maxwell, Michelle M.; Steegborn, Clemens; Schwarzschild, Michael A.; Outeiro, Tiago F.; Kazantsev, Aleksey G.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotro ...
In: PLoS One Bd. 10 (2015) Heft 1. - S. e0116919
doi:10.1371/journal.pone.0116919 ...

2014

Steegborn, Clemens
Structure, mechanism, and regulation of soluble adenylyl cyclases : similarities and difference ...
In: Biochimica et biophysica acta : Molecular Basis of Disease Bd. 1842 (2014) Heft 12. - S. 2535-2547
doi:10.1016/j.bbadis.2014.08.012 ...

Roessler, Claudia; Nowak, Theresa; Pannek, Martin; Gertz, Melanie; Nguyen, Giang T. T.; Scharfe, Michael; Born, Ilona; Sippl, Wolfgang; Steegborn, Clemens; Schutkowski, Mike
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and ...
In: Angewandte Chemie International Edition Bd. 53 (2014) Heft 40. - S. 10728-10732
doi:10.1002/anie.201402679 ...

Kleinbölting, Silke; van den Heuvel, Joop; Steegborn, Clemens
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide ...
In: The FEBS Journal Bd. 281 (2014) Heft 18. - S. 4151-4164
doi:10.1111/febs.12913 ...

Schweizer, Ulrich; Schlicker, Christine; Braun, Doreen; Köhrle, Josef; Steegborn, Clemens
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a per ...
In: Proceedings of the National Academy of Sciences of the United States of America Bd. 111 (2014) Heft 29. - S. 10526-10531
doi:10.1073/pnas.1323873111 ...

Suhre, Michael H.; Scheibel, Thomas; Steegborn, Clemens; Gertz, Melanie
Crystallization and preliminary X-ray diffractionanalysis of proximal thread matrix protein 1(P ...
In: Acta Crystallographica Section F Bd. 70 (2014) Heft 6. - S. 769-772
doi:10.1107/S2053230X14006165 ...

Kleinbölting, Silke; van den Heuvel, Joop; Kambach, Christian; Weyand, Michael; Leipelt, Martina; Steegborn, Clemens
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mamma ...
In: Acta Crystallographica Section F Bd. 70 (2014) Heft 4. - S. 467-469
doi:10.1107/S2053230X14004014 ...

Kleinbölting, Silke; Diaz, Ana; Moniot, Sébastien; van den Heuvel, Joop; Weyand, Michael; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its ...
In: Proceedings of the National Academy of Sciences of the United States of America Bd. 111 (2014) Heft 10. - S. 3727-3732
doi:10.1073/pnas.1322778111 ...

Suhre, Michael H.; Gertz, Melanie; Steegborn, Clemens; Scheibel, Thomas
Structural and functional features of a collagen-binding matrix protein from the mussel byssus
In: Nature Communications Bd. 5 (2014)
doi:10.1038/ncomms4392 ...

Schutkowski, Mike; Fischer, Frank; Roessler, Claudia; Steegborn, Clemens
New assays and approaches for discovery and design of Sirtuin modulators.
In: Expert Opinion on Drug Discovery Bd. 9 (2014) Heft 2. - S. 183-199
doi:10.1517/17460441.2014.875526 ...

2013

Nguyen, Giang Thi Tuyet; Gertz, Melanie; Steegborn, Clemens
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibi ...
In: Chemistry & Biology Bd. 20 (2013) Heft 11. - S. 1375-1385
doi:10.1016/j.chembiol.2013.09.019 ...

Nguyen, Giang Thi Tuyet; Schäfer, Susanne; Gertz, Melanie; Weyand, Michael; Steegborn, Clemens
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: bindin ...
In: Acta Crystallographica Section D Bd. 69 (2013) Heft 8. - S. 1423-1432
doi:10.1107/S0907444913015448 ...

Gertz, Melanie; Fischer, Frank; Nguyen, Giang Thi Tuyet; Lakshminarasimhan, Mahadevan; Schutkowski, Mike; Weyand, Michael; Steegborn, Clemens
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
In: Proceedings of the National Academy of Sciences of the United States of America Bd. 110 (2013) Heft 30. - S. E2772-E2781
doi:10.1073/pnas.1303628110 ...

Laurent, Gaëlle; German, Natalie J.; Saha, Asish K.; de Boer, Vincent C. J.; Davies, Michael; Koves, Timothy R.; Dephoure, Noah; Fischer, Frank; Boanca, Gina; Vaitheesvaran, Bhavapriya; Lovitch, Scott B.; Sharpe, Arlene H.; Kurland, Irwin J.; Steegborn, Clemens; Gygi, Steven P.; Muoio, Deborah M.; Ruderman, Neil B.; Haigis, Marcia C.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA ...
In: Molecular Cell Bd. 50 (2013) Heft 5. - S. 686-698
doi:10.1016/j.molcel.2013.05.012 ...

Moniot, Sébastien; Schutkowski, Mike; Steegborn, Clemens
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
In: Journal of Structural Biology Bd. 182 (2013) Heft 2. - S. 136-143

Lakshminarasimhan, Mahadevan; Rauh, David; Schutkowski, Mike; Steegborn, Clemens
Sirt1 activation by resveratrol is substrate sequence-selective.
In: Aging Bd. 5 (2013) Heft 3. - S. 151-154
http://www.impactaging.com/papers/v5/n3/abs/100542 ...

Suenkel, Benjamin; Fischer, Frank; Steegborn, Clemens
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.
In: Bioorganic & Medicinal Chemistry Letters Bd. 23 (2013) Heft 1. - S. 143-146
doi:10.1016/j.bmcl.2012.10.136 ...

Rauh, David; Fischer, Frank; Gertz, Melanie; Lakshminarasimhan, Mahadevan; Bergbrede, Tim; Aladini, Firouzeh; Kambach, Christian; Becker, Christian F. W.; Zerweck, Johannes; Schutkowski, Mike; Steegborn, Clemens
An acetylome peptide microarray reveals specificities and deacetylation substrates for all huma ...
In: Nature Communications Bd. 4 (2013) . - S. 2327
doi:10.1038/ncomms3327 ...

Lakshminarasimhan, Mahadevan; Curth, Ute; Moniot, Sébastien; Mosalaganti, Shyamal; Raunser, Stefan; Steegborn, Clemens
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and re ...
In: Bioscience Reports Bd. 33 (2013) Heft 3. - S. 395-404
doi:10.1042/BSR20120121 ...

2012

Middelhaufe, Sabine; Leipelt, Martina; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Identification of a haem domain in human soluble adenylate cyclase.
In: Bioscience Reports Bd. 32 (2012) Heft 5. - S. 491-499
doi:10.1042/BSR20120051 ...

Topal, Hüsnü; Fulcher, Nanette B.; Bitterman, Jacob; Salazar, Eric; Buck, Jochen; Levin, Lonny R.; Cann, Martin J.; Wolfgang, Matthew C.; Steegborn, Clemens
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathoge ...
In: Journal of Molecular Biology Bd. 416 (2012) Heft 2. - S. 271-286
doi:10.1016/j.jmb.2011.12.045 ...

Gertz, Melanie; Nguyen, Giang Thi Tuyet; Fischer, Frank; Suenkel, Benjamin; Schlicker, Christine; Fränzel, Benjamin; Tomaschewski, Jana; Aladini, Firouzeh; Becker, Christian F. W.; Wolters, Dirk; Steegborn, Clemens
A molecular mechanism for direct sirtuin activation by resveratrol.
In: PLoS One Bd. 7 (2012) Heft 11. - S. e49761
doi:10.1371/journal.pone.0049761 ...

Fischer, Frank; Gertz, Melanie; Suenkel, Benjamin; Lakshminarasimhan, Mahadevan; Schutkowski, Mike; Steegborn, Clemens
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
In: PLoS One Bd. 7 (2012) Heft 9. - S. e45098
doi:10.1371/journal.pone.0045098 ...

Moniot, Sébastien; Weyand, Michael; Steegborn, Clemens
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for ...
In: Frontiers in Pharmacology Bd. 3 (2012) Heft 16. - S. 16
doi:10.3389/fphar.2012.00016 ...

2011

Acin-Perez, Rebeca; Russwurm, Michael; Günnewig, Kathrin; Gertz, Melanie; Zoidl, Georg; Ramos, Lavoisier; Buck, Jochen; Levin, Lonny R.; Rassow, Joachim; Manfredi, Giovanni; Steegborn, Clemens
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
In: The Journal of Biological Chemistry Bd. 286 (2011) Heft 35. - S. 30423-30432
doi:10.1074/jbc.M111.266379 ...

Schlicker, Christine; Boanca, Gina; Lakshminarasimhan, Mahadevan; Steegborn, Clemens
Structure-based development of novel sirtuin inhibitors.
In: Aging Bd. 3 (2011) Heft 9. - S. 852-872
http://www.impactaging.com/papers/v3/n9/full/10038 ...

Russwurm, Michael; Schlicker, Christine; Weyand, Michael; Koesling, Doris; Steegborn, Clemens
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
In: Proteins Bd. 79 (2011) Heft 5. - S. 1682-1687
doi:10.1002/prot.22989 ...

Lakshminarasimhan, Mahadevan; Steegborn, Clemens
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets ...
In: Experimental Gerontology Bd. 46 (2011) Heft 2-3. - S. 174-177
doi:10.1016/j.exger.2010.08.024 ...

2010

Gertz, Melanie; Steegborn, Clemens
The mitochondrial apoptosis pathway and p66Shc : a regulatory redox enzyme or an adapter protei ...
In: Cell Cycle Bd. 9 (2010) Heft 22. - S. 4425-4426
doi:10.4161/cc.9.22.14053 ...

Gertz, Melanie; Steegborn, Clemens
The Lifespan-Regulator p66Shc in mitochondria : redox enzyme or redox sensor?
In: Antioxidants & Redox Signaling Bd. 13 (2010) Heft 9. - S. 1417-1428
doi:10.1089/ars.2010.3147 ...

Baur, Joseph A.; Chen, Danica; Chini, Eduardo N.; Chua, Katrin F.; Cohen, Haim Y.; de Cabo, Rafael; Deng, Chuxia; Dimmeler, Stefanie; Gius, David; Guarente, Leonard P.; Helfand, Stephen L.; Imai, Shin-Ichiro; Itoh, Hiroshi; Kadowaki, Takashi; Koya, Daisuke; Leeuwenburgh, Christiaan; McBurney, Michael; Nabeshima, Yo-Ichi; Neri, Christian; Oberdoerffer, Philipp; Pestell, Richard G.; Rogina, Blanka; Sadoshima, Junichi; Sartorelli, Vittorio; Serrano, Manuel; Sinclair, David A.; Steegborn, Clemens; Tatar, Marc; Tissenbaum, Heidi A.; Tong, Qiang; Tsubota, Kazuo; Vaquero, Alejandro; Verdin, Eric
Dietary restriction : standing up for sirtuins
In: Science Bd. 329 (2010) Heft 5995. - S. 1012-1013
doi:10.1126/science.329.5995.1012 ...

Gertz, Melanie; Steegborn, Clemens
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
In: Biochimica et Biophysica Acta : Proteins and proteomics Bd. 1804 (2010) Heft 8. - S. 1658-1665
doi:10.1016/j.bbapap.2009.09.011 ...

Hall, Rebecca A.; de Sordi, Luisa; Maccallum, Donna M.; Topal, Hüsnü; Eaton, Rebecca; Bloor, James W.; Robinson, Gary K.; Levin, Lonny R.; Buck, Jochen; Wang, Yue; Gow, Neil A .R.; Steegborn, Clemens; Mühlschlegel, Fritz A.
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
In: PLoS Pathogens Bd. 6 (2010) Heft 11. - S. e1001193
doi:10.1371/journal.ppat.1001193 ...

2009

Innocenti, Alessio; Hall, Rebecca A.; Schlicker, Christine; Scozzafava, Andrea; Steegborn, Clemens; Mühlschlegel, Fritz A.; Supuran, Claudiu T.
Carbonic anhydrase inhibitors : Inhibition and homology modeling studies of the fungal beta-car ...
In: Bioorganic & Medicinal Chemistry Bd. 17 (2009) Heft 13. - S. 4503-4509
doi:10.1016/j.bmc.2009.05.002 ...

Gertz, Melanie; Fischer, Frank; Leipelt, Martina; Wolters, Dirk; Steegborn, Clemens
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator pro ...
In: Aging Bd. 1 (2009) Heft 2. - S. 254-265
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC280600 ...

Schlicker, Christine; Hall, Rebecca A.; Vullo, Daniela; Middelhaufe, Sabine; Gertz, Melanie; Supuran, Claudiu T.; Mühlschlegel, Fritz A.; Steegborn, Clemens
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus ...
In: Journal of Molecular Biology Bd. 385 (2009) Heft 4. - S. 1207-1220
doi:10.1016/j.jmb.2008.11.037 ...

Steegborn, Clemens; Ohndorf, Uta-Maria; Schlicker, Christine
Crystallographic studies on carbonic anhydrases from fungal pathogens for structure-assisted dr ...
Supuran, Claudiu T. ; Winum, J.-Y. (Hrsg.): Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications.
Hoboken, NJ : Wiley, 2009. - S. 323-334 . - (Wiley Series in Drug Discovery and Development)

2008

Rauch, Annika; Leipelt, Martina; Russwurm, Michael; Steegborn, Clemens
Crystal structure of the guanylyl cyclase Cya2.
In: Proceedings of the National Academy of Sciences of the United States of America Bd. 105 (2008) Heft 41. - S. 15720-15725
doi:10.1073/pnas.0808473105 ...

Schlicker, Christine; Gertz, Melanie; Papatheodorou, Panagiotis; Kachholz, Barbara; Becker, Christian F. W.; Steegborn, Clemens
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
In: Journal of Molecular Biology Bd. 382 (2008) Heft 3. - S. 790-801
doi:10.1016/j.jmb.2008.07.048 ...

Innocenti, Alessio; Mühlschlegel, Fritz A.; Hall, Rebecca A.; Steegborn, Clemens; Scozzafava, Andrea; Supuran, Claudiu T.
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens C ...
In: Bioorganic & Medicinal Chemistry Letters Bd. 18 (2008) Heft 18. - S. 5066-5070
doi:10.1016/j.bmcl.2008.07.122 ...

Tammenkoski, Marko; Koivula, Katja; Cusanelli, Emilio; Zollo, Massimo; Steegborn, Clemens; Baykov, Alexander A.; Lahti, Reijo
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
In: Biochemistry Bd. 47 (2008) Heft 36. - S. 9707-9713
doi:10.1021/bi8010847 ...

Schlicker, Christine; Rauch, Annika; Hess, Ken C.; Kachholz, Barbara; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Structure-based development of novel adenylyl cyclase inhibitors.
In: Journal of Medicinal Chemistry Bd. 51 (2008) Heft 15. - S. 4456-4464
doi:10.1021/jm800481q ...

Gertz, Melanie; Fischer, Frank; Wolters, Dirk; Steegborn, Clemens
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
In: Proceedings of the National Academy of Sciences of the United States of America Bd. 105 (2008) Heft 15. - S. 5705-5709
doi:10.1073/pnas.0800691105 ...

Garzia, Livia; D'Angelo, A.; Amoresano, A.; Knauer, Shirley K.; Cirulli, C.; Campanella, C.; Stauber, R. H.; Steegborn, Clemens; Iolascon, A.; Zollo, Massimo
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell ...
In: Oncogene Bd. 27 (2008) Heft 13. - S. 1853-1864
doi:10.1038/sj.onc.1210822 ...

2007

Middelhaufe, Sabine; Garzia, Livia; Ohndorf, Uta-Maria; Kachholz, Barbara; Zollo, Massimo; Steegborn, Clemens
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerizat ...
In: Biochemical Journal Bd. 407 (2007) Heft 2. - S. 199-205
doi:10.1042/BJ20070408 ...

Mannherz, Hans Georg; Ballweber, Edda; Galla, Marco; Villard, Sylvie; Granier, Claude; Steegborn, Clemens; Schmidtmann, Anja; Jaquet, Kornelia; Pope, Brian; Weeds, Alan G.
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptid ...
In: Journal of Molecular Biology Bd. 366 (2007) Heft 3. - S. 745-755
doi:10.1016/j.jmb.2006.11.100 ...

2006

Kamenetsky, Margarita; Middelhaufe, Sabine; Bank, Erin M.; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
In: Journal of Molecular Biology Bd. 362 (2006) Heft 4. - S. 623-639
doi:10.1016/j.jmb.2006.07.045 ...

Mogensen, Estelle Geweiss; Janbon, Guilhem; Chaloupka, James; Steegborn, Clemens; Fu, Man Shun; Moyrand, Frédérique; Klengel, Torsten; Pearson, David S.; Geeves, Michael A.; Buck, Jochen; Levin, Lonny R.; Mühlschlegel, Fritz A.
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase ...
In: Eukaryotic Cell Bd. 5 (2006) Heft 1. - S. 103-111
doi:10.1128/EC.5.1.103-111.2006 ...

2005

Steegborn, Clemens; Litvin, Tatiana N.; Hess, Kenneth C.; Capper, Austin B.; Taussig, Ronald; Buck, Jochen; Levin, Lonny R.; Wu, Hao
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex wit ...
In: The Journal of Biological Chemistry Bd. 280 (2005) Heft 36. - S. 31754-31759
doi:10.1074/jbc.M507144200 ...

Steegborn, Clemens; Litvin, Tatiana N.; Levin, Lonny R.; Buck, Jochen; Wu, Hao
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and m ...
In: Nature Structural & Molecular Biology Bd. 12 (2005) Heft 1. - S. 32-37
doi:10.1038/nsmb880 ...

2004

Ye, Hong; Chen, Tzu-Chao; Xu, Xiaohui; Pennycooke, Micha; Wu, Hao; Steegborn, Clemens
Crystal structure of the putative adapter protein MTH1859.
In: Journal of Structural Biology Bd. 148 (2004) Heft 2. - S. 251-256
doi:10.1016/j.jsb.2004.06.004 ...

2003

Augustin, Martin A.; Reichert, Andreas S.; Betat, Heike; Huber, Robert; Mörl, Mario; Steegborn, Clemens
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymeriza ...
In: Journal of Molecular Biology Bd. 328 (2003) Heft 5. - S. 985-994
doi:10.1016/S0022-2836(03)00381-4 ...

Messerschmidt, Albrecht; Worbs, Michael; Steegborn, Clemens; Wahl, Markus C.; Huber, Robert; Laber, Bernd; Clausen, Tim
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: c ...
In: Biological Chemistry Bd. 384 (2003) Heft 3. - S. 373-386
doi:10.1515/BC.2003.043 ...

Xu, Guozhou; Rich, Rebecca L.; Steegborn, Clemens; Min, Tongpil; Huang, Yihua; Myszka, David G.; Wu, Hao
Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibi ...
In: The Journal of Biological Chemistry Bd. 278 (2003) Heft 7. - S. 5455-5461
doi:10.1074/jbc.M211607200 ...

2002

Stabler, Sally P.; Steegborn, Clemens; Wahl, Markus C.; Oliveriusova, Jana; Kraus, Jan P.; Allen, Robert H.; Wagner, Conrad; Mudd, S. Harvey
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
In: Metabolism Bd. 51 (2002) Heft 8. - S. 981-988
doi:10.1053/meta.2002.34017 ...

Rossoll, Wilfried; Kröning, Ann-Kathrin; Ohndorf, Uta-Maria; Steegborn, Clemens; Jablonka, Sibylle; Sendtner, Michael
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R ...
In: Human Molecular Genetics Bd. 11 (2002) Heft 1. - S. 93-105
doi:10.1093/hmg/11.1.93 ...

2001

Steegborn, Clemens; Danot, Olivier; Huber, Robert; Clausen, Tim
Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated ...
In: Structure Bd. 9 (2001) Heft 11. - S. 1051-1060
doi:10.1016/S0969-2126(01)00665-7 ...

Steegborn, Clemens; Laber, Bernd; Messerschmidt, Albrecht; Huber, Robert; Clausen, Tim
Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increase ...
In: Journal of Molecular Biology Bd. 311 (2001) Heft 4. - S. 789-801
doi:10.1006/jmbi.2001.4880 ...

Ohndorf, Uta-Maria; Steegborn, Clemens; Knijff, Rainer; Sondermann, Peter
Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.
In: The Journal of Biological Chemistry Bd. 276 (2001) Heft 29. - S. 27188-27196
doi:10.1074/jbc.M102891200 ...

Dorowski, Anja; Hofmann, Andreas; Steegborn, Clemens; Boicu, Marius; Huber, Robert
Crystal structure of paprika ferredoxin-NADP+ reductase. Implications for the electron transfer ...
In: The Journal of Biological Chemistry Bd. 276 (2001) Heft 12. - S. 9253-9263
doi:10.1074/jbc.M004576200 ...

2000

Steegborn, Clemens; Schneider-Hassloff, Henriette; Zeeb, Markus; Balbach, Jochen
Cooperativity of a protein folding reaction probed at multiple chain positions by real-time 2D ...
In: Biochemistry Bd. 39 (2000) Heft 27. - S. 7910-7919
doi:10.1021/bi000270u ...

Clausen, Tim; Kaiser, Jens T.; Steegborn, Clemens; Huber, Robert; Kessler, Dorothea
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persul ...
In: Proceedings of the National Academy of Sciences of the United States of America Bd. 97 (2000) Heft 8. - S. 3856-3861
doi:10.1073/pnas.97.8.3856 ...

Clausen, Tim; Schlegel, Anja; Peist, Ralf; Schneider, Eva; Steegborn, Clemens; Chang, Yuh-Shin; Haase, Andrea; Bourenkov, Gleb P.; Bartunik, Hans D.; Boos, Winfried
X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting ...
In: The EMBO Journal Bd. 19 (2000) Heft 5. - S. 831-842
doi:10.1093/emboj/19.5.831 ...

Schreiber, Valerie; Steegborn, Clemens; Clausen, Tim; Boos, Winfried; Richet, Evelyne
A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic bindin ...
In: Molecular microbiology Bd. 35 (2000) Heft 4. - S. 765-776
doi:10.1046/j.1365-2958.2000.01747.x ...

1999

Clausen, Tim; Wahl, Markus C.; Messerschmidt, Albrecht; Huber, Robert; Fuhrmann, Jens C.; Laber, Bernd; Streber, Wolfgang; Steegborn, Clemens
Cloning, purification and characterisation of cystathionine gamma-synthase from Nicotiana tabac ...
In: Biological Chemistry Bd. 380 (1999) Heft 10. - S. 1237-1242
doi:10.1515/BC.1999.157 ...

Steegborn, Clemens; Messerschmidt, Albrecht; Laber, Bernd; Streber, Wolfgang; Huber, Robert; Clausen, Tim
The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substr ...
In: Journal of Molecular Biology Bd. 290 (1999) Heft 5. - S. 983-996
doi:10.1006/jmbi.1999.2935 ...

Steegborn, Clemens; Clausen, Tim; Sondermann, Peter; Jacob, Uwe; Worbs, Michael; Marinkovic, Snezan; Huber, Robert; Wahl, Markus C.
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational con ...
In: The Journal of Biological Chemistry Bd. 274 (1999) Heft 18. - S. 12675-12684
doi:10.1074/jbc.274.18.12675 ...

Balbach, Jochen; Steegborn, Clemens; Schindler, Thomas; Schmid, Franz X.
A protein folding intermediate of ribonuclease T1 characterized at high resolution by 1D and 2D ...
In: Journal of Molecular Biology Bd. 285 (1999) Heft 2. - S. 829-842
doi:10.1006/jmbi.1998.2364 ...

1997

Steegborn, Clemens; Skládal, Petr
Construction and characterization of the direct piezoelectric immunosensor for atrazine operati ...
In: Biosensors and Bioelectronics Bd. 12 (1997) Heft 1. - S. 19-27
doi:10.1016/0956-5663(96)89086-5 ...

1996

Metzger, Armin U.; Schindler, Thomas; Willbold, Dieter; Kraft, Margot; Steegborn, Clemens; Volkmann, Andrea; Frank, Rainer W.; Rösch, Paul
Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation.
In: FEBS Letters Bd. 384 (1996) Heft 3. - S. 255-259
doi:10.1016/0014-5793(96)00314-6 ...

Sprinzl, Mathias; Steegborn, Clemens; Hübel, Frank; Steinberg, Sergey
Compilation of tRNA sequences and sequences of tRNA genes.
In: Nucleic Acids Research Bd. 24 (1996) Heft 1. - S. 68-72
doi:10.1093/nar/24.1.68 ...

Fakultät für Biologie, Chemie und Geowissenschaften
Lehrstuhl für Biochemie


Prof. Dr. Clemens Steegborn

Fachgruppe Chemie

Universität Bayreuth
Universitätsstrasse 30
95447 Bayreuth

Telefon: +49 (0)921 / 55-2420
E-Mail: clemens.steegborn@uni-bayreuth.de
Homepage: Lehrstuhl Biochemie

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